Blar i forfatter "Midtvedt, Karsten"

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    • Blood Pressure Treatment in Kidney Transplant Recipients - Can We Improve? 

      Onsøien, Mari Olsen; Midtvedt, Karsten; Reisæter, Anna Varberg; Aasarød, Knut; Waldum-Grevbo, Bård; Vikse, Bjørn Egil; Eriksen, Bjørn Odvar; Åsberg, Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-25)
      <i>Background</i> - Hypertension in kidney transplant (KTx) recipients is common, affecting both patient and graft survival. Annual data from the Norwegian Renal Registry reveal that <50% of adult (>18 y) KTx recipients reach target blood pressure (BP) ≤130/80 mm Hg. The aim of this study was to identify the determinants of failure to achieve BP control.<br><br> <i>Methods</i> - In conjunction ...

    • Early fulminant BK polyomavirus-associated nephropathy in two kidney transplant patients with low neutralizing antibody titers receiving allografts from the same donor 

      Lorentzen, Elias Myrvoll; Henriksen, Stian; Kaur, Amandeep; Kro, Grete Birkeland; Hammarström, Clara; Hirsch, Hans H; Midtvedt, Karsten; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed; Mastergradsoppgave; Master thesis, 2020-01-10)
      <i>Background</i> - BK Polyomavirus (BKPyV) causes premature graft failure in 1 to 15% of kidney transplant (KT) recipients. High-level BKPyV-viruria and BKPyV-DNAemia precede polyomavirus-associated nephropathy (PyVAN), and guide clinical management decisions. In most cases, BKPyV appears to come from the donor kidney, but data from biopsy-proven PyVAN cases are lacking. Here, we report the early ...

    • Elevated Terminal C5b-9 Complement Complex 10 Weeks Post Kidney Transplantation Was Associated With Reduced Long-Term Patient and Kidney Graft Survival 

      Witczak, Bartlomiej J; Pischke, Søren E.; Reisæter, Anna V.; Midtvedt, Karsten; Ludviksen, Judith K; Heldal, Kristian; Jenssen, Trond; Hartmann, Anders; Åsberg, Anders; Mollnes, Tom E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-25)
      Background: The major reason for graft loss is chronic tissue damage, as interstitial fibrosis and tubular atrophy (IF/TA), where complement activation may serve as a mediator. The association of complement activation in a stable phase early after kidney transplantation with long-term outcomes is unexplored.<p> <p>Methods: We examined plasma terminal C5b-9 complement complex (TCC) 10 weeks ...

    • Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients 

      Pihlstrøm, Hege; Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Gatti, Francesca; Hammarström, Clara Louise; Kasprzycka, Monika; Wang, Junbai; Haraldsen, Guttorm; Mjøen, Geir; Dahle, Dag Olav; Midtvedt, Karsten; Eide, Ivar Anders; Hartmann, Anders; Holdaas, Hallvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-16)
      Following a successful renal transplantation circulating markers of inflammation may remain elevated, and systemic inflammation is associated with worse clinical outcome in renal transplant recipients (RTRs). Vitamin D-receptor (VDR) activation is postulated to modulate inflammation and endothelial function. We aimed to explore if a synthetic vitamin D, paricalcitol, could influence systemic ...

    • One-year protocol biopsies from ABO-incompatible renal allografts compared with a matched cohort of ABO-compatible allografts 

      Dörje, Christina; Mjøen, Geir; Strøm, Erik Heyerdahl; Holdaas, Hallvard; Jenssen, Trond Geir; Øyen, Ole; Akkøk, Cigdem Ahaein; Småstuen, Milada C; Midtvedt, Karsten; Reisæter, Anna Varberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-21)
      Abstract: Introduction: Early acute antibody-mediated rejection (ABMR) occurs more frequently in ABO-incompatible (ABOi) than in ABO-compatible (ABOc) kidney transplantation. This could lead to increased inflammation/scarring in the ABOi grafts. Protocol biopsy data in ABOi kidney recipients are scarce.<p> <p>Methods: A single-center retrospective matched cohort study was conducted. Eighty ...